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Swap the base, swap the alkene 🔀 E2: Zaitsev vs Hofmann 2-bromo-2,3-dimethylbutane KOtBu: which alkene? 👇 E2 elimination: small base (ethoxide) → Zaitsev, the more substituted alkene (~70 %). Bulky base (tert-butoxide) can't reach the inner H, takes the methyl H → Hofmann, the less substituted alkene (~72 %). #organicchemistry #orgo #E2 #chemistrystudent
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Swap the base, swap the alkene 🔀 E2: Zaitsev vs Hofmann 2-bromo-2,3-dimethylbutane KOtBu: which alkene? 👇 E2 elimination: small base (ethoxide) → Zaitsev, the more substituted alkene (~70 %). Bulky base (tert-butoxide) can't reach the inner H, takes the methyl H → Hofmann, the less substituted alkene (~72 %). #organicchemistry #orgo #E2 #chemistrystudent
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