Clindamycin is associated with an increased risk of C. difficile infection (CDI) Clostridioides difficile infection (CDI) is a common cause of health care–associated infections, contributing to excess morbidity, mortality, and health care costs Antibiotics are the greatest risk factor for Clostridioides difficile infection (CDI). Risk for CDI varies across antibiotic types and classes. Optimal prescribing and stewardship recommendations require comparisons of risk across antibiotics. However, ma