Neurotrophin binding to p75NTR activates a JNK signaling pathway causing apoptosis of developing neurons. JNK, through a series of intermediates, activates p53 and p53 activates Bax which initiates …

In this review, we begin by introducing the landmark discoveries, structures, tissue expression, and activation mechanisms of the JNK pathway. Next, we come to the focus of this work: a …

The c-Jun N-terminal kinase (JNK) pathway is one of the major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling pathway. It functions in the control of a number of cellular …

5 days ago · Expert-reviewed interactive pathway providing a current overview of SAPK/JNK Signaling.

Aug 1, 2024 · Subsequent sections provide a detailed exploration of the interactions between various molecules and pathways within JNK signaling, emphasizing how the cellular context influences the …

Jan 1, 2024 · The JNK pathway can be triggered by G protein-coupled receptors (GPCRs) that utilize G proteins such as G12/13. The JNK pathway controls a number of biological functions, such as the …

The JNK MAPK pathway is predominantly activated by stress stimuli and plays important roles in development, apoptosis, cell growth, inflammatory, and immune responses.

Analysis of this pathway has shown that JNK is required for p73-mediated apoptosis induced by the DNA damaging agent cisplatin and it involves the phosphorylation of p73 at several serine and …

Dec 5, 2006 · This review will concentrate on describing the involvement of the JNK pathway in the context of different diseases and the potential to adopt the JNK pathway components as therapeutic...

View our interactive JNK Signal Transduction Pathway, and find antibodies and other products for your targets.