ILC2 cells, or type 2 innate lymphoid cells are a type of innate lymphoid cell. They are derived from the common lymphoid progenitor (CLP) and belong to the lymphoid lineage.

Group 2 innate lymphoid cells (ILC2 cells) are able to produce type 2 cytokines and to mediate type 2 immune protection and tissue homeostasis. ILC2 cells have often been considered to …

Mar 30, 2022 · More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be members of a family of innate immune cells consisting of five subsets that form a first line …

ILC2s serve crucial functions in many different tissues, but are especially enriched in barrier tissues, such as the lung, gut and skin. Here, we will focus on lung ILC2s and their role in …

Jun 2, 2025 · While it was widely held that tissue-resident ILC2 act as the earliest sentinels against the breaching of mucosal tissues, circulating ILC2 now add more nuance to how ILC2 …

In the intestine, in response to a helminth infection, epithelial cells secrete high levels of IL-25, activating ILC2 cells. ILC2s produce IL-13, which drives the differentiation of additional …

Group 2 innate lymphoid cells (ILC2s) play critical roles in the induction of type 2 inflammation, response to parasite infection, metabolic homeostasis, and tissue repair.

Sep 11, 2023 · Although Th2 cells are undoubtedly central to the pathogenesis of allergic asthma, the discovery of group 2 innate lymphoid cells (ILC2s) has added another layer of complexity …

Sep 1, 2025 · Group 2 innate lymphoid cells (ILC2s) play a canonical role in the induction of type 2 inflammation by producing type 2 cytokines, including interleukin (IL)-5 and IL-13, in …

Apr 30, 2018 · Group 2 innate lymphoid cells (ILC2) represent an evolutionary rather old but only recently identified member of the family of innate lymphoid cells and have received much …