D. E. Shaw Research develops and uses paradigm-shifting computational technologies to design precisely targeted new therapeutics for the treatment of disease.

Successful candidates will contribute to building and deploying AI-powered systems, including automated code generation, smart agents, retrieval-augmented generation (RAG) frameworks, …

D. E. Shaw Research conducts drug discovery programs both independently and in collaboration with other biopharmaceutical companies and research laboratories.

D. E. Shaw Research has brought together a team of extraordinary contributors from a variety of disciplines, and from both academia and industry. We welcome inquiries from exceptionally …

D. E. Shaw Research makes a variety of resources and scientific publications available without cost for members of the research community.

If this description of “Who We Are” seems like it might be a good match with Who You Are, we welcome you to explore the various opportunities for joining us at D. E. Shaw Research.

D. E. Shaw Research welcomes internship applications from undergraduate and graduate students from a range of scientific and technical disciplines.

We have always been a research driven organization, with activities ranging from the design of new supercomputers to the design of new drug molecules.

This tutorial assumes that someone has prepared the Desmond‐Maestro environment for you, either by installing the packages available from Schrödinger LLC or the Academic release of …

The software described in this guide is copyrighted and licensed by D. E. Shaw Research under separate agreement. This software may be used only according to the terms and conditions of …