Tight end Kincaid will miss a second consecutive game when the Bills host the Niners at Highmark Stadium on Sunday.

The NFL's two best running backs meet Sunday in a potential Super Bowl preview. Seattle, Arizona and San Francisco also have ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

As the 49ers prepare for their Week 13 matchup against the Bills, Brock Purdy will be the signal caller after being listed as ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

On Saturday night, ESPN's Adam Schefter reported that San Francisco 49ers quarterback Brock Purdy, officially listed as ...

While making updates to the team’s injury report, the San Francisco 49ers announced that left tackle Trent Williams will miss ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.

It looks like the San Francisco 49ers might get their quarterback back under center in time for a Week 13 matchup with the ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

The 49ers just promoted veteran cornerback Nick McCloud from the practice squad to the active roster one day before their Week 13 road game against ...