San Francisco played without four key players - quarterback Brock Purdy, left tackle Trent Williams, defensive end Nick Bosa ...

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco ...

Here’s how you can watch, stream and listen to the game. Bills vs. 49ers will air on NBC. Mike Tirico will be on play-by-play ...

The San Francisco 49ers and Buffalo Bills will clash on "Sunday Night Football." Here's how to watch the Week 13 NFL game ...

San Francisco quarterback Brock Purdy took part in some light throwing after missing his first career game because of an ...

Getting blown out in Green Bay following another squandered late lead the previous week against Seattle has quickly turned ...

Getting blown out at Green Bay following another squandered late lead the previous week against Seattle has quickly turned ...

The San Francisco 49ers are on the wrong end of .500, and one NFL exec thinks Kyle Shanahan is due a large portion of the ...

Ahead of the regular season, the Green Bay Packers' Week 12 matchup with the San Fransisco 49ers was predicted to be a ...

San Francisco head coach Kyle Shanahan discussed what it will take for the 49ers to ignite receiver Deebo Samuel’s production ...

This Sean McDermott stat should give Buffalo Bills fans confidence entering their Week 13 matchup with the San Francisco ...

The San Francisco 49ers dropped their record to 5-6 after a 38-10 loss against the Green Bay Packers in Week 12. Today, Pro ...