The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Ever since making the switch from high school receiver to running back in college, Isaac Guerendo has had few opportunities ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

With a Buffalo Bills Week 14 game coming up against the Los Angeles Rams, all eyes are going to be on the 10-2 Bills to see ...

Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) missed his second contest in a row due to hip and oblique injuries.

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

ProFootballTalk founder Mike Florio has an intriguing idea for a change of scenery for Kyle Shanahan. Appearing on “The Rich ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

BUFFALO, N.Y. (WKBW) — For the second time this season and the 14th time in his career, Buffalo Bills quarterback Josh Allen ...