Significant advancement on product portfolio, including enrollment in the OCS-01 DIAMOND Phase 3 program in DME and OCS-05 Phase 2 ACUITY trial ...

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While we did not detect an upregulation of the pro-inflammatory TNF receptor type I (TNFR1), we observed significant upregulation of the anti-inflammatory TNF receptor type II (TNFR2) in ...

However, telocytes also secrete VEGF, a pro-angiogenic factor; concomitantly they are positive for TNFR1 and may also act as pro-inflammatory cells (Sanches et al., 2020). In terms of pathological ...

It shares receptors with TNF-α, influencing inflammation and immune cell function through both TNFR1 and TNFR2. Its interactions with these receptors can either promote or inhibit tumor progression, ...

Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.

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Brain inflammation is a hallmark of multiple sclerosis. Using novel spatial transcriptomics methods, the authors provide solid evidence for a gradient of immune genes and inflammatory markers from the ...