A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Stanford type A aortic dissection (AD) is a degenerative aortic remodeling disease and carries a high mortality rate. It ...

The p38 MAPK regulates intracellular signaling pathways in response to environmental stress. Its inhibition blocks the production of inflammation-causing cytokines, such as IL-1β and TNF-α ...

In a recent study published in Nature, researchers examine how sleep impacts inflammation and recovery following a heart ...

Microscopy images of monocytes in the brain of a mouse after a heart attack. Schematic of hypothesized mechanism: after a heart attack, monocytes are released from the bone marrow and recruited to the ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

In contrast, biologics zero in on specific pathways ... for signaling that keeps it going. Each works by preventing a particular cytokine from causing inflammation. Tumor Necrosis Factor, or ...

Next, the Herbert team sought to find the specific signaling molecules involved and ... and allowing pro-inflammatory cytokines like TNF to be expressed." This pro-inflammatory environment is ...

Shufeng Jiedu Capsules (SFJD), a traditional Chinese medicine preparation, are widely used in the clinical treatment of influenza, yet their mechanism of action remains unclear. This study aimed ...

An analysis of adverse event reports published in the journal Pharmacoepidemiology showed that methotrexate users who took ...