A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Stanford type A aortic dissection (AD) is a degenerative aortic remodeling disease and carries a high mortality rate. It ...

The p38 MAPK regulates intracellular signaling pathways in response to environmental stress. Its inhibition blocks the production of inflammation-causing cytokines, such as IL-1β and TNF-α ...

Microscopy images of monocytes in the brain of a mouse after a heart attack. Schematic of hypothesized mechanism: after a heart attack, monocytes are released from the bone marrow and recruited to the ...

In a recent study published in Nature, researchers examine how sleep impacts inflammation and recovery following a heart ...

Dr. Ma adds, "Our results show that BB1 prevented the TNF-α increase in intestinal tight junction permeability via a toll-like receptor (TLR)-2 signal transduction pathway inhibition of NF-kB p50 ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

In contrast, biologics zero in on specific pathways ... for signaling that keeps it going. Each works by preventing a particular cytokine from causing inflammation. Tumor Necrosis Factor, or ...

Next, the Herbert team sought to find the specific signaling molecules involved and ... and allowing pro-inflammatory cytokines like TNF to be expressed." This pro-inflammatory environment is ...

Shufeng Jiedu Capsules (SFJD), a traditional Chinese medicine preparation, are widely used in the clinical treatment of influenza, yet their mechanism of action remains unclear. This study aimed ...

The Taiwanese biotech has launched a phase 1/2 trial to test its small molecule cancer therapy in children and young adults ...