Q3 highlights: * Patients without previous exposure to biologics ** Patients with an inadequate response to TNF inhibitors Third quarter 2024 financial results As of September 30, 2024, MoonLake held ...

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM ...

Among patients with rheumatoid arthritis, JAK inhibitors were slightly more effective for reducing pain at 3 and 12 months when compared with TNF inhibitors.

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

The lesion-specific 12-month cumulative incidence of radiographic radiation necrosis was 3.5% in the combination arm vs 3.2% in the immune checkpoint inhibitor–first arm. Although combining the two ...

The use of IL-17 inhibitors in patients with psoriasis was associated with an increased risk for fungal infections when compared with other biologics.

Skeletal stem cells have been isolated from various tissues, including periosteum and bone marrow, where they exhibit key functions in bone biology and hematopoiesis, respectively. The role of ...

Tumour Necrosis Factor TNF is crucial for defence but can drive chronic inflammation linked to arthritis and autoimmune diseases when overproduced ...

Investigators aimed to highlight aspects that may predict the time to relapse among patients with psoriasis who discontinued use of biologic therapy.

KEY POINTS A 22-year-old White man presented to the emergency department with a 2-month history of progressive fatigue, intermittent abdominal pain, constipation, and dyspnea. He had gained 27 kg over ...

A recent meta-analysis published in JAMA Neurology has revealed that tumor necrosis factor (TNF) inhibitors, widely used in treating autoimmune diseases, may increase the risk of ...