These ligand–receptor pairs also mediate ... the level of signalling that each one triggers and whether different TNF–TNFR interactions induce different cellular responses.
They were totally oblivious to the added TNF. Indeed ... and dephosphorylation events. Death receptors, it was assumed, must signal in a similar fashion. Here came the second major surprise ...
Tuberculosis and some other granulomatous infections are likely to occur more frequently among patients treated with monoclonal antibodies than among those treated with soluble TNF receptors.
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