The finding that their expression is increased following immune-cell activation suggests that ... approaches for therapy based on targeting TNF–TNF receptor (TNFR) interactions: one is to ...

Tuberculosis and some other granulomatous infections are likely to occur more frequently among patients treated with monoclonal antibodies than among those treated with soluble TNF receptors.

At the time, only two death receptors were known: tumour necrosis factor receptor 1 (TNFR1) and Fas/CD95. It was a risky move as all my grant support was for research on matrix biology ...