The finding that their expression is increased following immune-cell activation suggests that ... approaches for therapy based on targeting TNF–TNF receptor (TNFR) interactions: one is to ...

Creative BioMart, one of the world leading biotechnology companies that serving science, is pleased to expand its offerings for cytokin ...

Toll-like receptors (TLRs) and their signalling pathways ... The production of IL-6 and TNF-α is also induced by imiquimod 20. The dsRNA mimic IPH-3102 activates NF-κB signalling and type ...

Upon activation, T cells can upregulate different activation markers such as CD69 (an early activation marker), members of the TNF receptor superfamily including co-stimulatory molecules like CD134 ...

Objective Anifrolumab is a fully human immunoglobulin G 1 κ monoclonal antibody specific for subunit 1 of the type I interferon (IFN) α receptor. In a phase IIb ... The concentration of TNF-related ...

The main challenge in inhibiting PAR2 activity arises from the fact that several proteases are capable of PAR2 activation and have specific binding pokets, leading to different conformational changes.

Dysregulated neutrophil activation plays a significant role in sepsis. This study shows that the membrane protein CMTM3 is ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in ...

Rezpegaldesleukin was evaluated in two randomized, double-blind, placebo-controlled Phase 1b trials in patients with moderate ...

The following is a summary of “Role of baseline soluble tumor necrosis factor receptor 2 as a biomarker in primary podocytopathy: Implications for renal impairment and disease progression,” published ...

The effects of ET are mediated through interaction with two classes of cell surface receptors. The type A receptor (ET-A) has been associated with vasoconstriction and cell growth while the type B ...