Although they share a defined target, TNF, therapeutic disparity has been seen between these agents, which has sparked consideration of their pharmacology and mechanisms of action. These issues ...

However, since TNF is a cytokine with pleiotropic effects, interfering with many immunological functions and pathways, the precise mechanisms by which these agents reduce inflammation in these ...

Tumour Necrosis Factor TNF is crucial for defence but can drive chronic inflammation linked to arthritis and autoimmune diseases when overproduced ...

Nothing was known at the time about the spectrum of TNF's biological actions and its molecular mechanisms of action. In fact, the only actions then associated with TNF were the tumor-necrotizing ...

2010 Future Medicine Ltd. Cite this: Anti-TNF-α Agents in the Treatment of Immune-mediated Inflammatory Diseases: Mechanisms of Action and Pitfalls - Medscape - Nov 01, 2010.