FDA GRANTS FULL APPROVAL TO AMGEN'S IMDELLTRA® IN EXTENSIVE STAGE SMALL CELL LUNG CANCER

Amgen (NASDAQ: AMGN) announced today that the U.S. Food and Drug Administration (FDA) has granted full approval to IMDELLTRA® (tarlatamab-dlle) for the treatment of adult patients with extensive stage ...
Frontiers

Interplay Between Nutrition, Genetics, and Liver Health: Mechanisms and Interventions

Emerging evidence highlights the complex interplay between diet, genetic background, and metabolic regulation in liver ...
eLife

Analysis of cancer mutations introduced into the Drosophila Notch Negative Regulatory Region uncovers a diversity of regulatory outcomes

This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...
EMBO Press

NANOG governs cell metabolism and redox homeostasis in human naïve embryonic stem cells

NANOG has multifaceted roles in naïve hESCs, orchestrating transcriptional, metabolic, and epigenetic signatures in naïve hESCs, and governing acetyl-CoA synthesis, bivalent metabolism, and redox ...
Frontiers

Unraveling the Mechanisms of Atherosclerosis: From Molecular Pathways to Clinical Outcomes

Atherosclerosis is a complex disorder that develops over many years. It begins with subtle changes in the vascular wall and progresses into a condition that ...