In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

The Buffalo Bills (9-2) are moving on to their their Week 13 contest against the San Francisco 49ers (5-6). Prior to that, ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

Brock Purdy missed the 49ers' last game against the Packers, but the Bills are preparing as if he's playing on Sunday night.

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

Erving (6-5, 313) was originally drafted by the Cleveland Browns as the 19 th overall selection of the 2015 NFL Draft.

San Francisco 49ers coach Kyle Shanahan explained why star linebacker Dre Greenlaw is participating in "mock games" during ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Kansas City Chiefs' Isiah Pacheco and Charles Omenihu will play Friday against the Las Vegas Raiders, provided they don't ...

The Buffalo Bills will have to wait and see what happens with tight end Dalton Kincaid as his status for this week is up in ...

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.