Introduction Tezepelumab, a human monoclonal antibody targeting TSLP, inhibits T2 inflammation leading to a fall in both the blood eosinophil count (Eos) and fractional exhaled nitric oxide (FeNO) ...

Introduction With improving cancer outcomes, indeterminate pulmonary lesions following radically-treated cancer are increasingly common, posing a diagnostic challenge of underlying aetiology. Existing ...

Environmental factors, here taken to include pollutants, lifestyle factors and behaviours, can play an important role in serious, chronic pathologies with large societal and economic costs, including ...

Background Asthma remains the most common chronic disease in children and the UK has some of the poorest asthma outcomes in Europe. The socio demographic inequalities contribute to severe asthma ...

8 Biometrics, Late-stage Development, Respiratory and Immunology, BioPharmaceuticals RandD, AstraZeneca, Cambridge, UK 9 Late-stage Development, Respiratory and ...

2 Institute of Respiratory Medicine, University of Sydney, NSW, Australia 3 South Western Sydney Clinical School, University of New South Wales, NSW, Australia Background: Sahaja Yoga is a traditional ...

Atypical radiological manifestation of sarcoidosis presenting with an anterior mediastinal mass ...

Introduction and Objectives Gene therapy for cystic fibrosis is approaching clinical trials. Using a lentiviral vector pseudotyped with Sendai virus fusion and hemagglutinin-neuraminidase proteins, ...

Background Bronchoalveolar lavage (BAL) is essential in determining the efficacy of novel therapies in alpha-1 antitrypsin deficiency (AATD). These require initial proof-of-concept demonstration that ...

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1 NIHR Collaboration for Leadership in Applied Health Research and Care for North West London, Chelsea and Westminster NHS Foundation Trust, London, UK 2 NIHR Respiratory Biomedical Research Unit of ...

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