Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Josh Allen grabbed at his left hand and jumped in pain after he took on 49ers linebacker De'Vondre Campbell Sr.

The San Francisco 49ers are reeling. They've lost two straight games to fall to 5-6 and under .500 for the fourth time this ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

San Francisco 49ers quarterback Brock Purdy official game status revealed for Week 13 primetime matchup against the Buffalo ...

The San Francisco 49ers are extremely banged up going into their Week 13 showdown with the Buffalo Bills. However, they will ...

The Bills return from their bye and will look to keep pace with the Kansas City Chiefs at the top of the AFC. Josh Allen has ...

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's ...

San Francisco 49ers quarterback Brock Purdy and cornerback Charvarius Ward are set to return to action Sunday night against ...

San Francisco 49ers quarterback Brock Purdy missed the team's loss to the Green Bay Packers in Week 12 with a shoulder injury ...

Brock Purdy, who missed last week's loss to the Packers with a shoulder injury, will play tonight against the Buffalo Bills ...

Sunday Night Football prop picks and NFL SGP for San Francisco 49ers vs. Buffalo Bills for sites like PrizePicks, Underdog ...