A primary function of the TNF superfamily molecules is to regulate cell survival. In addition, signals from OX40, 4-1BB, CD27 and DR3 also synergize with T-cell receptor (TCR) signals to allow ...

Several reports now demonstrate a role for the ligand–receptor interaction of TL1A (also known as TNF ligand superfamily member 15) and DR3 in the pathogenesis of RA, [1–4] thus adding a new ...

Upon activation, T cells can upregulate different activation markers such as CD69 (an early activation marker), members of the TNF receptor superfamily including co-stimulatory molecules like CD134 ...

TNFRSF11B is a member of the TNF-receptor superfamily that functions as a soluble decoy receptor. It is binding to RANK ligand, thus preventing the interaction with RANK and thereby inhibiting the ...

ILTs along with KIRs constitute the immunoglobulin-like receptor superfamily. Another group of receptors are the C-type lectin superfamily, which consists of a disulfide-linked heterodimer of CD94 ...

Specially Appointed Professor, Department of Translational Research and Drug Development, Faculty of Medicine, Dentistry and ...

The following is a summary of “Role of baseline soluble tumor necrosis factor receptor 2 as a biomarker in primary podocytopathy: Implications for renal impairment and disease progression,” published ...

Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or ...

When it comes to the NFL Week 6 Thursday Night Football game, it's 49ers all day. San Francisco has historically dominated the series with the Seahawks, winning five straight against Seattle ...