eLife1d
CD131 Contributes to Ulcerative Colitis Pathogenesis by Promoting Macrophage Infiltration
Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...
PipelineReview.com3d
Xencor Doses First Subject in Phase 1/2 Study of XmAb®942 in Development for Patients with Inflammatory Bowel Disease
PASADENA, CA, USA I November 04, 2024 I Xencor, Inc. (NASDAQ: XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies for the ...
The EMBO Journal7d
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy
Eicosapentaenoic acid (EPA) prevents diabetic cardiomyopathy (DC) by promoting the transition of macrophages from M1 to Mox ...
A Pit Viper Snake Can 'See' You, Even in the Dark
Pit vipers also carry venom in twin glands behind their eyes, delivered through movable fangs that can be folded up against ...
Nature14d
Targeting Toll-like receptors: emerging therapeutics?
Toll-like receptors (TLRs) and their signalling pathways ... The production of IL-6 and TNF-α is also induced by imiquimod 20. The dsRNA mimic IPH-3102 activates NF-κB signalling and type ...
Nature14d
The role of TNF superfamily members in T-cell function and diseases
A primary function of the TNF superfamily molecules is to regulate cell survival. In addition, signals from OX40, 4-1BB, CD27 and DR3 also synergize with T-cell receptor (TCR) signals to allow ...
New York Post20d
Saints’ bizarre timeout in ‘TNF’ loss to Broncos completely baffles Al Michaels
Al Michaels had no use for the Saints’ first-half foolishness Thursday night. Michaels sarcastically ripped the Saints for taking a timeout before a kneeldown to end the first 30 minutes in ...
Medscape20d
TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease
Schematic of TNF inhibitors and their mode of action. Receptor (i.e. etanercept, lenercept) and antibody based (i.e. infliximab, adalimumab, golimumab) anti-TNF biologics inhibit both solTNF and ...
Yardbarker20d
'TNF' takeaways: Broncos rushing attack, defense show out in blowout win over Saints
The Denver Broncos improved to 4-3 after a one-sided 33-10 blowout victory over the New Orleans Saints on "Thursday Night Football." Here are four takeaways from the action: Broncos leaned on ...
Sporting News20d
Is Courtland Sutton playing today? Broncos WR held without target in TNF win over Saints
The Broncos got off to a hot start versus the Saints on Thursday night, heading into the locker room with a 16-3 lead at the half. Denver quarterback Bo Nix was prolific through the first two ...
Broncos Wire20d
Sean Payton's Broncos run over Saints in 33-10 win on 'TNF'
Sean Payton’s Denver Broncos ran over the New Orleans Saints in a 33-10 Thursday Night Football victory to kick off Week 7 of the 2024 NFL season on Oct. 17. The game marked Payton’s return ...
Sky21d
Liam Payne: One Direction singer had the X Factor - but less support than young stars have today
Initially rejected from the X Factor at the age of 14, when Liam Payne returned to audition again two years later Simon Cowell felt the teenager from Wolverhampton was ready. But if anyone can ...