This suggests that CGRP signaling through RAMP1 on macrophages plays a crucial role in lesion growth and pain associated with ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

Stanford type A aortic dissection (AD) is a degenerative aortic remodeling disease and carries a high mortality rate. It ...

By inhibiting receptor-ligand interactions in sebaceous glands, antibodies may be able to treat certain skin conditions.

Shufeng Jiedu Capsules (SFJD), a traditional Chinese medicine preparation, are widely used in the clinical treatment of influenza, yet their mechanism of action remains unclear.

Q3 2024 net product revenue of $112.2 million, representing 73% year-over-year growth –– ARCALYST 2024 expected net ...

Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass ...

These ligand–receptor pairs also mediate ... the level of signalling that each one triggers and whether different TNF–TNFR interactions induce different cellular responses.

Toll-like receptors (TLRs) and their signalling pathways have therapeutic ... The production of IL-6 and TNF-α is also induced by imiquimod 20. The dsRNA mimic IPH-3102 activates NF-κB ...

Following the co-culture, we measured the levels of Tumor Necrosis Factor-α (TNFα), Interferon ... which could be due to a lack of co-stimulation signaling compared to that mediated by the chimeric ...

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Tuberculosis and some other granulomatous infections are likely to occur more frequently among patients treated with monoclonal antibodies than among those treated with soluble TNF receptors.