Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

These ligand–receptor pairs also mediate ... the level of signalling that each one triggers and whether different TNF–TNFR interactions induce different cellular responses.

Creative BioMart, one of the world leading biotechnology companies that serving science, is pleased to expand its offerings for cytokin ...

Eli Lilly (LLY) announced results from two, multi-year, Phase 3 studies that showed patients treated with mirikizumab sustained stable, ...

Toll-like receptors (TLRs) and their signalling pathways have therapeutic ... The production of IL-6 and TNF-α is also induced by imiquimod 20. The dsRNA mimic IPH-3102 activates NF-κB ...

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL ... not respond to antitumor necrosis factor agents or ...

Shufeng Jiedu Capsules (SFJD), a traditional Chinese medicine preparation, are widely used in the clinical treatment of influenza, yet their mechanism of action remains unclear.

Functional enrichment analysis highlighted pathways such as the C-type lectin receptor signaling pathway, tumor necrosis factor signaling pathway, and hypoxia-inducible factor-1 signaling pathway.

Following the co-culture, we measured the levels of Tumor Necrosis Factor-α (TNFα), Interferon ... which could be due to a lack of co-stimulation signaling compared to that mediated by the chimeric ...

Objective Anifrolumab is a fully human immunoglobulin G 1 κ monoclonal antibody specific for subunit 1 of the type I interferon (IFN) α receptor. In a phase IIb ... The concentration of TNF-related ...

Receptor dimerization ... hepatocellular necrosis, reactive oxygen species production, steatosis, and inflammation in experimental NASH (68). Additional studies in diabetic mice have reported that ...

TNFRSF11B is a member of the TNF-receptor superfamily that functions as a soluble ... 18 A study from Fichtner-Feigl, however, showed that IL13 signalling through IL13Ralpha2 is involved in the ...