Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

Stanford type A aortic dissection (AD) is a degenerative aortic remodeling disease and carries a high mortality rate. It ...

The finding that their expression is increased following immune-cell activation suggests that ... approaches for therapy based on targeting TNF–TNF receptor (TNFR) interactions: one is to ...

Toll-like receptors (TLRs) and their signalling pathways ... The production of IL-6 and TNF-α is also induced by imiquimod 20. The dsRNA mimic IPH-3102 activates NF-κB signalling and type ...

Upon activation, T cells can upregulate different activation markers such as CD69 (an early activation marker), members of the TNF receptor superfamily including co-stimulatory molecules like CD134 ...

IL-17A signals through its receptor, IL-17RA ... with exogenous recombinant mouse IL-17A protein showed functional activation of IL-17RA signaling as demonstrated by increased chemokine secretion.

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Tuberculosis and some other granulomatous infections are likely to occur more frequently among patients treated with monoclonal antibodies than among those treated with soluble TNF receptors.

Al Michaels had no use for the Saints’ first-half foolishness Thursday night. Michaels sarcastically ripped the Saints for taking a timeout before a kneeldown to end the first 30 minutes in ...

The Denver Broncos improved to 4-3 after a one-sided 33-10 blowout victory over the New Orleans Saints on "Thursday Night Football." Here are four takeaways from the action: Broncos leaned on ...

He’s obviously not Lamar Jackson, but Bo Nix can be in that second tier of rushing quarterbacks that includes everyone other than Jackson. Ran for 20 touchdowns in his two years at Oregon. Huge ...

Initially rejected from the X Factor at the age of 14, when Liam Payne returned to audition again two years later Simon Cowell felt the teenager from Wolverhampton was ready. But if anyone can ...