This important study presents a technically rigorous and carefully controlled analysis of the signalling potential of cancer-associated gain-of-function Notch alleles. The work is clearly presented, ...

Northeastern University researchers used an original machine learning tool to predict how genetic mutations cause a rare ...

By fusing enzyme fragments to antibodies, researchers from Institute of Science Tokyo, Japan, developed an innovative enzyme ...

Throughout evolution, pathogenic microorganisms, such as bacteria, viruses, and fungi, have developed sophisticated defense ...

A pig kidney with one genetic change functioned in a brain-dead human for 61 days, more than doubling previous records.

New live-cell imaging data show that Telomir-1 markedly lowers intracellular iron levels at submicromolar concentrations in ...

Chondrocytes play a crucial role in skeletal development. Many bones, such as those in the arms and legs, are formed through ...

We elucidated that DNA methyltransferase 1 (Dnmt1), an epigenetic regulator, properly controls bone elongation by modulating energy metabolism in ...

Proteins play a critical role in cellular function by interacting with other biomolecules; missense variants that cause loss of protein function can lead to a broad spectrum of genetic disorders.

ABSTRACT: Soil cadmium (Cd) and lead (Pb) pollution is becoming increasingly serious; heavy metals are accumulating in soil and agricultural products, and vegetables, as an indispensable part of ...

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