eLife

Synaptic density and relative connectivity conservation maintain circuit stability across development

The authors have performed a potentially valuable new kind of analysis in connectomics, mapping to an interesting developmental problem of synaptic input to sensory neurons. While the analysis itself ...
EMBO Press

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actions

A proteolytically inactive BACE1 knock-in (BACE1-KI, D289N) is compared with a BACE1 knockout (BACE1-KO) mouse to dissect ...
eLife

Multi-barrier unfolding of the double-knotted protein, TrmD–Tm1570, revealed by single-molecule force spectroscopy and molecular dynamics

This study investigates the folding and unfolding behavior of the doubly knotted protein TrmD-Tm1570, providing insight into the molecular mechanisms underlying protein knotting. The findings reveal ...
Communications of the ACM

Advancing AI in Agriculture through Large-Scale Collaborative Research

Five federally funded AI institutes provide a backbone for agriculture-focused AI research. The grand challenge facing global ...