This is a preview. Log in through your library . Abstract To explore the possible role of proteolytic step(s) in receptor-mediated endocytosis of insulin, the effects of inhibitors of various classes ...

IRS-2 gene was silenced using small interfering RNAs (siRNAs). Nuclear translocation and interaction of IRS-2 with v-src was determined using subcellular fractionation, confocal microscopy, and ...

In a leap forward for diabetes research, researchers reveal that the feel-good hormone, dopamine, regulates insulin secretion through a heteromeric complex of receptors, thereby providing new targets ...

TWIST1 is a major regulator of epithelial mesenchymal transition process, essential in cancer metastasis. Cancer cells increase glucose uptake capabilities to meet their high energy requirements. In ...

During the American Diabetes Association national conference this year in Philadelphia, scientists gathered to discuss recent advances in this field at a session on positive and negative elements in ...

A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin ...

Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck Institute ...

Good, old-fashioned diet and exercise might keep you young by reducing the action of insulin in the brain, researchers reported on Thursday. They created mutant mice that over-ate, got fat and even ...

Estrogen may protect diabetes patients from cardiomyopathy, according to research led by a Texas A&M AgriLife scientist and published in the June issue of the American Heart Association journal ...

How mitochondrial dysfunction (MD) and endoplasmic reticulum (ER) stress act as central drivers of IR and metabolic disease progression. The reciprocal reinforcement between the dysfunction and ...