Guanylate-binding proteins (GBPs) form a family of dynamin-related large GTPases which mediate important innate immune functions. They were proposed to form oligomers upon GTP binding/hydrolysis, but ...

An investigation into cellular components in bacteria has unexpectedly uncovered a feature with relevance across many life ...

Although there are more than 150 guanosine triphosphate (GTP)–binding proteins, or GTPases, only the GTPase KRas G12C has proved susceptible to small-molecule drugs. That’s because it’s tough to find ...

A GIF showing a protein mimicking IL-2 binding to IL-2 receptors, then changing shape in response to an effector molecule, which forces it off of one of the receptors. A protein mimicking IL-2 called ...