Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

Yong Yi, Deshi Chen, Juan Ao, Wenhua Zhang, Jianqiao Yi, Xiaokun Ren, Junjie Fei, Fengtian Li, Mengmeng Niu, Hu Chen, Yangkun Luo, Zhijun Luo, Zhi-Xiong Jim Xiao Proceedings of the National Academy of ...

Kinases are enzymes that catalyze the transfer of phosphate groups from high-energy donor molecules to specific target molecules. These intracellular phosphorylation cascades initiated by protein ...

Ongoing clinical trials are exploring whether modulating kinase activity can either suppress the immune response in autoimmune disorders or enhance it for antiviral therapies and cancer immunotherapy.