SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games

Before looking at SportsbookWire staff's Week 13 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com. The Detroit Lions (10-1 straight up) head into their Thanksgiving home game vs.

After some Thanksgiving Day and Black Friday treats, we're now out of the holiday and into a juicy slate that still leaves a lot of meat on the bone for our NFL