The St. Louis Cardinals and Chicago Cubs are currently in the midst of the tightest NL Central race in recent memory. Which team has the edge on Sunday night?

The St. Louis Cardinals (48-42) and the Chicago Cubs (53-36) play the final game of their 3-game series Sunday night. First pitch from Wrigley Field is at 6:10 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's MLB odds around the Cardinals vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

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Pregame analysis and predictions of the St. Louis Cardinals vs. Chicago Cubs MLB game to be played on July 6, 2025 on ESPN.

The Chicago Cubs hit eight home runs against the St. Louis Cardinals, setting a franchise record for most home runs in a game, while tying the MLB record for most home runs hit on the 4th of July.

Pete Crow-Armstrong and Michael Busch headlined a historic day against the St. Louis Cardinals on Friday afternoon at Wrigley Field.

An update to the previous announcement,” a Cubs official said into the press box microphone. “Michael Busch’s home run now represents the 26th time this has happened.” Such was the nature of Friday’s 4th of July game between the Cubs and the St.