The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, and its functions include attaching chromatin domains to the nuclear periphery and localizing some ...

Children with Hutchinson-Gilford Progeria Syndrome (HGPS) race through life against an unfairly fast clock. By 6-18 months of age, they show signs of premature aging including hair loss, stiff joints, ...

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the ...

Lamins are members of the intermediate filament (IF) superfamily and are classified as type V IFs. However, the structure of lamin genes indicates that they were possibly the evolutionary pregenitors ...

In a study with lab-grown mouse cells, Johns Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell's "command center" — its ...

A tremendous amount of genetic material must be packed into the nucleus of every cell—a tiny compartment. One of the biggest challenges in biology is to understand how certain regions of this highly ...

In a study with lab-grown mouse cells, researchers say they have found that a protein that helps form a structural network under the surface of the cell's 'command center' -- its nucleus -- is key to ...

Hundreds of diseases are associated with a flaw in the LMNA gene, and researchers at Alfaisal University in Saudi Arabia are picking apart its behaviour to diagnose some of the most serious conditions ...

In a study with lab-grown mouse cells, Johns Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell’s “command center” — its ...