the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and impaired insulin secretion. Therefore, we propose here that the ...

7 In pancreatic β-cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1α pathway, facilitating glycolysis and insulin release.

In addition to impaired insulin secretion, type 2 diabetic patients ... This not only adds to our understanding of biology and signaling pathways in cells, but, more importantly, it is leading ...

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is ...

Type 2 diabetes is a disease with highly diverse progression pathways ... diversity of type 2 diabetes in terms of insulin ...