The cohesin subunit Scc1 returns and reconstitutes the complex with Smc1–Smc3 in late mitosis upon DNA double-strand breaks, although it does not participate in homologous recombination-driven MAT ...

Osaka, Japan - BRCA1, a protein that is well-known for its role in hereditary breast cancer, is an important part of the cellular system that repairs double-strand DNA breaks. Now, researchers from ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

Divya Ramalingam Iyer, Naoya Harada, Connor Clairmont, Lige Jiang, David Martignetti, Huy Nguyen, Yizhou Joseph He, Dipanjan Chowdhury, Alan D. D’Andrea Proceedings of the National Academy of Sciences ...

One of the hallmarks of DNA damage is the rapid spreading of phosphorylated histone H2A (γ-H2AX) around a DNA double-strand break (DSB). In the budding yeast Saccharomyces cerevisiae, nearly all H2A ...

This illustration shows proteins and DNA in the process of DNA repair. RecA proteins (gold) cradle a single-stranded DNA (brown) that searches for homology with a DNA template (purple). The template ...

When a double strand break, or DSB -- the most severe form of DNA damage -- occurs, the repair pathway may insert or delete genes at the break site or potentially rearrange genes throughout the strand ...

Zhi “Zack” Zheng is a member of molecular biologist Scott Keeney's lab. Zhi “Zack” Zheng, who is scheduled to receive his PhD from the Gerstner Sloan Kettering Graduate School of Biomedical Sciences ...

A day in the life of DNA can be rough. It gets yanked across a dividing cell, zapped by radiation, and assaulted by chemicals. Luckily, cells have developed a complex set of repair mechanisms to ...

Experimentation may be what first comes to mind when one contemplates the process of scientific research, but sometimes the best way to understand a system is to simply observe it in its native state.