Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

In prokaryotic cells, transcription (DNA to mRNA) and translation (mRNA to protein) are so closely linked that translation ...

Cell division, a process fundamental to life, still holds surprises. Researchers from the University of Zurich and the ...

Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

Before a cell divides, its DNA is replicated so that each daughter cell inherits the same genetic information. The two copies, known as "sister chromatids," are held together by a ring-shaped protein ...

It has been discovered that there are multiple types of DNA sites prone to breakage, beyond those previously known. This was announced by RIKEN, Kobe University, and JST. By examining cells one by one ...

Every time a cell divides, it must copy roughly three billion letters of DNA with near-perfect fidelity. That copying process, DNA replication, is among the most demanding operations a cell performs, ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions, it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

A representative figure showing that HELQ-deficient cells fail to undergo normal fork slowing after MMC (a crosslinking agent) treatment, consistent with defective fork reversal. Every time a cell ...