Recent studies reestablish the importance to memory processes of calpain, a protease first hypothesized to play a crucial role in memory 25 years ago. A second high-profile paper in as many months has ...

We found that patients with LGMD2A whom did not harbor null-alleles, while having no detectable level of calpain 3, were still able to regenerate their muscles. It is possible that minute quantities ...

Uncontrolled activation of calpain can lead to necrotic cell death and irreversible tissue damage. We have discovered an intrinsic mechanism whereby the autolysis-generated protease core fragment of ...

Toxic forms of tau come in many shapes and sizes, ranging from tiny fragments to large oligomers to hyperphosphorylated forms entrenched within neurofibrillary tangles. According to new findings ...

Calpains are Ca 2+-dependent cysteine proteases (proteolytic enzymes with cysteine in the catalytic site) that modulate cellular function. In humans, 14 independent genes encode members of the calpain ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Blade Therapeutics, a biopharmaceutical company advancing novel anti-fibrotic therapies, today announced publication in Science Translational Medicine (11 ...

If a protein breaks up, it can no longer carry out its specific function. Calpains, therefore, influence the biological function of the substrates?proteins, in this case. The exact effect of this ...

Nature article shows exactly how calpastatin regulates calpain. Scientists at St. Jude Children’s Research Hospital used a combination of x-ray crystallography and nuclear magnetic resonance (NMR) ...

Cerebellar ataxia is a condition of the cerebellum that causes an inability to coordinate muscle movements. A new study describes a new genetic mutation as an additional cause of ataxia in humans and ...

A team of scientists from the United States has recently revealed that small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease exhibit potent antiviral ...

Twenty-two patients with genetically verified LGMD2A (age 37 ± 14 years) participated in this study described in (Table 1) and also in two previous studies. [24,25] All investigations were performed ...