St. Agnes Academy was founded in 1905 by Mother Pauline Gannon, O.P., Prioress of the Dominican Sisters of Houston, Texas. The Academy opened on February 11, 1906, at its former location at 3901 Fannin. It was in operation at that site until September 1963 when the present-day campus opened at 9000 Bellaire Boulevard in Sharpstown. St. Agnes numbers more than 10,000 graduates, many of whom now have daughters, granddaughters, and even great-granddaughters who are Academy students or alumnae.In 1917 St. Agnes was accredited by the University of Texas and the State Board of Education.