Homepage | Archives of Disease in Childhood
WEB2 days ago · Archives of Disease in Childhood (ADC) is an international and peer-reviewed journal specialising in child health, covering the perinatal period through to adolescence. As an official journal of the Royal College of Paediatrics and Child Health, ADC provides paediatricians with the most recent, relevant and original research reports ...
Ehlers–Danlos syndrome: how to diagnose and when to perform …
WEBThe term Ehlers–Danlos syndrome (EDS) encompasses a group of inherited connective tissue disorders. The manifestations of EDS can be seen in skin, joints, blood vessels and internal organs and vary from mild to severe and life threatening. Each subtype is a separate and different condition. The genetic basis of many subtypes has now been elucidated, confirming heterogeneity.
O24 Ivermectin in children: what is the right dose to achieve ...
WEBResults Clearance per kilogram was higher in children than in adults, with a median (90% confidence interval) of 0.35 (0.12–0.73) L/h/kg in children compared to 0.20 (0.10–0.31) L/h/kg in adults. As a result, ivermectin exposure in children following a 200 µg/kg dose is ∼30% lower than in adults. An increased dose of 250 and 300 µg/kg would be needed in school-aged children (6–12 ...
The effects of television on child health: implications and ...
WEBThe exposure of American children and adolescents to television continues to exceed the time they spend in the classroom: 15 000 hours versus 12 000 hours by the time they graduate.1 According to recent Nielsen data, the average child and/or adolescent watches an average of nearly three hours of television per day.2These numbers have not decreased significantly over the past 10 years.3 By the ...
Understanding randomised controlled trials | Archives of Disease …
WEBThe hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled trial, is discussed. Issues that need to be considered during the critical appraisal of randomised controlled trials, such as assessing the validity of trial methodology and the magnitude and ...
Current evidence-based recommendations on investigating …
WEBIntroduction Global developmental delay (GDD) affects 1%–3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are exogenous, genetic (non-metabolic) or genetic (metabolic). Recent advances in biotechnology and genetic testing mean that the investigations available to perform for children under 5 years are ...
Understanding systematic reviews and meta-analysis
WEBThis review covers the basic principles of systematic reviews and meta-analyses. The problems associated with traditional narrative reviews are discussed, as is the role of systematic reviews in limiting bias associated with the assembly, critical appraisal, and synthesis of studies addressing specific clinical questions. Important issues that need to be considered when appraising a systematic ...
PACS (picture archiving and communication systems): filmless …
WEBA picture archiving and communication system (PACS) is a computerised means of replacing the roles of conventional radiological film. This review describes the Hammersmith PACS, and discusses the advantages and disadvantages of PACS systems.
Fetal alcohol spectrum disorders: an overview of current evidence …
WEBEstimates for the UK suggest that alcohol consumption during pregnancy and prevalence of fetal alcohol spectrum disorder (FASD)—the most common neurodevelopmental condition—are high. Considering the significant health and social impacts of FASD, there is a public health imperative to prioritise prevention, interventions and support. In this article, we outline the current state of play ...
Tachypnoea in a well baby: what to do next? | Archives of Disease …
WEBAdditionally symptoms will be milder if it is a stenosis rather than complete atresia. Techniques for diagnosis include placing a cold mirror/metal spoon under the nostril to look for condensation, passing a small nasogastric tube, or putting a few drops of saline in the nostril and looking for bubbles. 29.